Fig. 1

Airn expression were downregulated in diabetic hearts, while overexpression of Airn ameliorates diabetes-induced cardiac dysfunction. A Schematic diagram of the experimental protocol. B qRT-PCR analysis of Airn expression in CTRL and DM hearts by intramyocardially AAV-9 virus injection. C Random blood glucose levels. D IPGTT glucose levels. E Representative M-mode echocardiography images in CTRL and DM hearts by intramyocardially AAV-9 virus injection. F–I Echocardiography data analysis. J Representative Doppler echocardiography images. K E/A ratio. L Representative images of the morphologies of the hearts stained by hematoxylin and eosin staining; Scale bar = 200 mm. M Representative images of wheat germ agglutinin staining and quantitative analysis of the cross-sectional area of cardiomyocytes. Scale bar = 20 μm. Data are presented as means ± SEM. *p < 0.05; **p < 0.01. n = 6 mice