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Fig. 6 | Biology Direct

Fig. 6

From: Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis

Fig. 6

Synj2bp silencing in the mouse liver upregulates mitochondria fatty acid respiration capacity. A–D Comparative quantitative proteomic analysis of WAM-enriched fractions prepared from livers of mice injected with control AAV8-shScrambled and AAV8-shSynj2bp (livers collected at 3 h postprandial). A The graph shows that silencing Synj2bp, which reduces the amount of wrapper associated with mitochondria (Fig. 2E), reduces the percentage of ER proteins but proportionally increases only the amount of mitochondrial proteins, not that of other subcellular compartments. B, C Reactome biological process analysis of the pathways up-regulated in Synj2bp-silenced mouse livers. D Estimation statistics analysis [24, 25] of the WAM proteomics data related to the indicated proteins. Pdk4 and Hmgcs2 up-regulation in Synj2bp-silenced livers indicates activation of mitochondrial FA respiration

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