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Fig. 1 | Biology Direct

Fig. 1

From: Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma

Fig. 1

Distinct copper-regulated genes (CRGs) expression and modification characteristics and mutation-related analysis across 32 cancer types. A Somatic alteration in pan-cancer (29/32). Top histogram, tumor mutation rate; Bottom histogram, an indication of cohort and nucleotide mutation type; Right histograms, frequency of somatic alterations in each of CRGs. B Spearman’s correlation between transcriptional levels of CRGs and these genes’ promoter methylation; Significantly positive and negative correlation are marked in red and purple, respectively. C The Spearman’s correlation of CRGs between transcriptional level and somatic copy number alterations. D The heatmap shows differential expression fold change of CRGs in each cancer (23/32). The red and blue points are marked significantly up-, and down-regulated genes, respectively. E The overall survival (OS) and progression-free survival (PFS) of CRGs in 32 cancers. The risk and protective factor genes are marked red and blue, respectively. The border frame means significant differences in high- and low expression of genes

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