Table 2 Performance analysis of in silico docking of the predicted crRNA structures with the Cas13a proteins
From: In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials
Cas13 protein structure | Combination | iRMSD | Template | Model |
|---|---|---|---|---|
5W1H | CONTRAfold + Rosetta | 12.615 | Free | 9 |
5W1H | ContextFold + Rosetta | 12.818 | Free | 7 |
5W1H | IPKnot + RNAComposer | 12.987 | Used | 3 |
5W1I_AB | ContextFold + Rosetta | 12.753 | Free | 1 |
5W1I_AB | CONTRAfold + Rosetta | 13.547 | Free | 1 |
5W1I_AB | ContextFold + Rosetta | 13.7 | Free | 3 |
5W1I_CD | IPKnot + RNAComposer | 13.026 | Used | 3 |
5W1I_CD | CONTRAfold + Rosetta | 13.41 | Free | 7 |
5W1I_CD | ContextFold + RNAComposer | 13.515 | Used | 2 |
5WLH | ContextFold + RNAComposer | 6.256 | Free | 1 |
5WLH | IPKnot + Rosetta | 10.055 | Free | 1 |
5WLH | IPKnot + RNAComposer | 10.876 | Free | 5 |