Fig. 5
From: Alamandine alleviated heart failure and fibrosis in myocardial infarction mice
Oxidative stress enhancement reversed the effects of Ala in NRCFs. a, b tBHP reversed the inhibiting effect of Ala on OGD-induced ROS increase in NRCFs. c–e tBHP reversed the inhibiting effect of Ala on OGD-induced the increases of collagen I, α-SMA and TGF-β mRNA in NRCFs. f–i tBHP reversed the inhibiting effect of Ala on OGD-induced the increases of collagen I, α-SMA and TGF-β proteins in NRCFs. j–l tBHP reversed the inhibiting effect of Ala on OGD-induced the increases of Bax/Bcl2 and cleaved caspase3/caspase3 in NRCFs. m, n tBHP reversed the inhibiting effect of Ala on OGD-induced the increase of TUNEL positive cells in NRCFs. N = 5 in each group (a, b), N = 3 in each group (c, l), and N = 4 in each group (m, n). The results are expressed as mean ± SEM