Fig. 3

Association of protein variability with other genomic and biological features. A Fraction (in percent) of variance of protein variability explained by other properties. The “total explained” fraction is estimated using multivariable regression. The fraction explained by individual properties is estimated using ANOVA. The cells, corresponding to properties, excluded by Akaike criterion based stepwise reduction of multivariable regression model, are shaded in gray. B Average variability of subsets of genes categorized by other properties. C Average variability of subsets of genes categorized by COG functional categories. Functional categories are the following: J—Translation, ribosomal structure and biogenesis; K—Transcription; L—Replication, recombination and repair; D—Cell cycle control, cell division, chromosome partitioning; V—Defense mechanisms; T—Signal transduction mechanisms; M—Cell wall/membrane/envelope biogenesis; N—Cell motility; W—Extracellular structures; O—Posttranslational modification, protein turnover, chaperones; X—Mobilome: prophages, transposons; C—Energy production and conversion; G—Carbohydrate transport and metabolism; E—Amino acid transport and metabolism; F—Nucleotide transport and metabolism; H—Coenzyme transport and metabolism; I—Lipid transport and metabolism; P—Inorganic ion transport and metabolism; Q—Secondary metabolites biosynthesis, transport and catabolism; R—General function prediction only; S—Function unknown; Color scale from blue to red is proportional to the value