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Fig. 2 | Biology Direct

Fig. 2

From: A genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins

Fig. 2

A The radar plot shows the sequence identity between the TIR domain of TRAM (blue) and TRIF (orange) of respective organism wrt human TRAM-TIR and TRIF-TIR. Also, the inner most line (yellow) represent sequence identity percentage of TRAM- TIR and TRIF-TIR within the same organism. B Sequence similarity network, with edges between 45 and 100% pairwise sequence identity, and clustering of sequences into subfamilies. Representative organisms from each taxon are represented across each subfamily. In the clustering method, TRAM protein separates distinctively from the other clusters. For the TRIF representatives, Actinopteri and Chondrichthyes separate as a distinct cluster. Mammals represents an individual cluster closer to clusters of Aves, Bifurcata, Crocodylia, Cryptodira, and Amphibia. Interestingly, members from the Amphibia clusters separates notably from the Reptiles clusters (Bifurcata, Crocodylia, Cryptodira). Thereby, explaining the extent of differences amongst these sequence in accordance with evolutionary perspective. C An unrooted phylogeny showing different subfamilies. The left cluster represents TRAM and right represents TRIF orthologs

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Biology Direct

ISSN: 1745-6150

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