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Fig. 4 | Biology Direct

Fig. 4

From: An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy

Fig. 4

Unsupervised hierarchical clustering analysis based on CpGs methylation data of the 382 patients selected from TCGA-COAD and READ projects. The lines on the heatmap represent the 1000 most differentially methylated CpGs probes between HM, HM-like and non-HM groups. The columns correspond to the 382 patients. Inside the cells of the heatmap are reported the β-values which represent the methylation rate of the probes. The HM patients are reported in yellow; the HM-like patients in red while the non-HM patients in blue. The hierarchical clustering dendrogram supported three distinct tumour groups: CIMP-H (n = 57) defined by an high rate of CpGs probes methylated; CIMP-L (n = 107) with low rate of CpGs probes methylated and non-CIMP (n = 218) characterized by the absence of CpGs probes methylated

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