Fig. 7
From: Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis
Evolution of chryseoviridin systems. A 16S rRNA subtree for Chryseobacteria species bearing chryseoviridin system is schematically shown on the left (complete tree is available in Additional file 14). Chryseoviridin loci are mapped to respective genomes. Genes are shown by block arrows, roughly to scale, color code is provided in the inset on the right upper corner. Chryseobacterium gregarium system in which CdnA3 peptides was experimentally characterized is shown separately (16S rRNA gene in this genome is incomplete and cannot be included in the tree reconstruction) [20]. Numbers below the precursor genes correspond to 4 clades in the respective tree (Additional file 5: Figure S5). Gray arrows indicate exchange of the genes by horizontal gene transfer (see discussion in the text). B Consensus sequences of four groups of chryseoviridin precursors. Consensus for multiple alignment of each cluster was determined as described in “Material and Methods” section. Conserved positions that can be involved in formation of ester or amide bonds are highlighted by red and correspond to the experimentally determined linkages [20], GG-motifs are highlighted by blue and characteristic microviridin group leader motif is highlighted by green