Fig. 4

LINC00885 regulated proliferation and apoptosis of CC cells through modulating miR-3150b-3p expression. SiHa cells were transfected with pcDNA3.1, pcDNA3.1/LINC00885, pcDNA3.1/LINC00885 + NC mimics, and pcDNA3.1/LINC00885 + miR-3150b-3p mimics respectively. HeLa cells were transfected with sh-NC, sh-LINC00885#1, sh-LINC00885#1 + anti-NC, or sh-LINC00885#1 + miR-3150b-3p inhibitor. A CCK-8 was used to examine proliferation of SiHa and HeLa cells transfected with indicated plasmids. B–C EdU and colony formation assays were used to examine proliferation of HeLa cells under indicated conditions. D TUNEL assay was used to evaluate apoptosis of HeLa cells in different groups. E Western blot analysis was done for the measurement of apoptosis-related genes in SiHa and HeLa cells with the transfection of indicated plasmids. *P < 0.05, **P < 0.01