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Fig. 6 | Biology Direct

Fig. 6

From: Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma

Fig. 6

YY1 transcriptionally activates LOXL1-AS1 transcription in HCC cells. A UCSC database showed the possible transcription factors for LOXL1-AS1. B qRT-PCR analysis was done for the measurement of YY1 and LOXL1-AS1 levels in cells with transfection of sh/YY1 and pcDNA3.1/YY1. C, D DNA motif of YY1 and the binding sites of YY1 and LOXL1-AS1 promoter were obtained from JASPAR database. E ChIP assay proved the binding correlation between YY1 and LOXL1-AS1 promoter. F Luciferase reporter assay confirmed the binding of YY1 and LOXL1-AS1 promoter and detected the exact binding site. **P < 0.01

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Biology Direct

ISSN: 1745-6150

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