The p53 family member p73 in the regulation of cell stress response

Biology Direct

Table 2 Intracellular cancer hallmarks and p73 functions in specific cancers

Cancer	Apoptosis, cell cycle	Replicative Immortality	Genomic instability, DSB response	Altered metabolism	Role of p73 isoforms in cancer	TP73 in tumor compared to normal tissue
Non-small cell lung carcinoma (NSCLC)	[24,25,26,27,28,29]	[30, 31]		[32, 33]	[34,35,36]
Lung adenocarcinomas	[27]		[20]		[37, 38]	2.95
Hepatocellular carcinoma (HCC)	[39]
Cervix carcinoma	[40,41,42]			[41]	[22, 43, 44]	15.2
Melanoma	[45]			[46]
Osteosarcoma	[47,48,49,50,51]		[52, 53]	[54, 55]		5.4
Glioblastoma	[56, 57]				[58, 59]	5.2
Medulloblastoma				[60, 61]	[62]	–
B-cell lymphoma	[63]	[64]	[65]		[66]	33.6
T-cell lymphoma	[67, 68]
Acute myeloid leukemia	[69,70,71,72]
Chronic myelogenous leukemia (CML)	[73,74,75]			[73]
Breast cancer	[76,77,78,79]		[80]	[81]	[82]	1.2
Colorectal cancer	[25, 78, 83, 84]	[85,86,87]	[88]		[84, 89]	9.6
Esophageal adenocarcinoma	[90]		[91,92,93]		[94]	1.1
Thyroid cancer	[95]
Ovarian cancer	[96, 97]				[98]	4.1
Pancreatic cancer					[99, 100]	3.15
Neuroblastoma	[26, 101,102,103]			[104]
Squamous carcinoma	[105, 106]				[107, 108]	1.26

The rightmost column represents the Tp73 expression in tumor tissue (Tp73Tum) in comparison to normal tissue (Tp73Norm) as a ration log2(Tp73Tum + 1)/log2(Tp73Norm + 1) [23]

ISSN: 1745-6150