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Table 1 Expression levels of p73 or p73 isoforms in various cancers

From: The p53 family member p73 in the regulation of cell stress response

Cancer

Changes of p73 isoform expression

Conclusions

References

NSLC

p73↑

Total p73 does not predict prognosis

[10]

NSLC

DNp73↑

DNp73 is associated with poor prognosis

[11]

Breast

p73↓

Upregulation is associated with lower pathological grade

[13]

Breast

p73↑ in 27%

Upregulation is association with higher pathological grade

[12]

Breast

p73↑ in 38% alpha, gamma, delta epsilon and phi isoforms detected

p73 does not have a tumor suppressor role

[5]

Esophagus

DNp73↑ in 60%

Leads to b-catenin/TCF activation

[14]

Gliomas

p73↑ ependymomas and pilocytic astrocytomas

P73 does not influence p21 and MDM2 expression

[15]

Low grade gliomas

DNp73↑, TAp73↑, DeltaEx2-3↑

DeltaEx2-3 upregulation predicts progression

[16]

High grade gliomas

TAp73↑, DNp73↓

TAp73 is upregulated in high grade gliomas

[17]

Glioblastomas

DNp73↑, TAp73↓ by PCR

13 GBM samples examined by IB

[21]

Cervical

p73↑

Higher p73 protein is associated with better survival

[22]