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Fig. 5 | Biology Direct

Fig. 5

From: Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis

Fig. 5

The tumor-suppressing role of SNHG8 silencing on the proliferation, migration and EMT process of TNBC cells were reversed by PYGO2. A RT-qPCR was used to detect PYGO2 overexpression efficiency in TNBC cells. B The proliferation of TNBC cells transfected with sh/NC, sh/SNHG8#1 or sh/SNHG8#1 + pcDNA3.1-PYGO2 was examined by colony formation assay. C Transwell assay was utilized to assess the number of migrated TNBC cells of sh/NC, sh/SNHG8#1 or sh/SNHG8#1 + pcDNA3.1-PYGO2 group. D RT-qPCR and western blot assays were conducted to examine E-cadherin, N-cadherin, Vimentin, MMP2 or MMP7 mRNA and protein levels in TNBC cells of sh/NC, sh/SNHG8#1 or sh/SNHG8#1 + pcDNA3.1-PYGO2 group. **P < 0.01

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