Skip to main content

Table 3 Top ten most significant paths, their cancer-type sign and prognosis factor according to the literature

From: Common pathways and functional profiles reveal underlying patterns in Breast, Kidney and Lung cancers

Path BRCA KIRC LUAD Prognosis Factor
PPAR:CD36 DOWN UP DOWN Metastatic potential and immunotherapy resistance [15,16,17],
UP: poor prognosis
Axon Guidance: CFL1 DOWN DOWN DOWN Invasion, metastasis progression, therapy resistance,
DOWN: better prognosis
Melanogenesis: TYRP1 UP DOWN DOWN Metastatic potential,
DOWN: poor prognosis
Thyroid hormone: RCAN1 DOWN DOWN DOWN Metastatic potential, treatment resistance (sunitinib) [18, 19],
DOWN: poor prognosis
Aldosterone synthesis and secretion: PDE2A DOWN DOWN DOWN Invasive and metastatic potential [20],
DOWN: poor prognosis
Aldosterone-regulated sodium reabsorption: FXYD4 UP DOWN DOWN Recurrence-free survival following surgery [21],
DOWN: poor prognosis
Aldosterone-regulated sodium reabsorption: SCNN1A DOWN DOWN DOWN Proliferation, migration, poor prognosis [22, 23],
DOWN: better prognosis
Aldosterone-regulated sodium reabsorption: KCNJ1 DOWN DOWN DOWN Prognostic factor of patient’s survival, Metastatic potential [24],
DOWN: worse prognosis
Salivary secretion: RYR3 DOWN DOWN DOWN Unfavorable prognosis and upcoming malignant conversion [25],
DOWN: poor prognosis
Proteoglycans in cancer: CTNNB1 DOWN DOWN DOWN Unfavorable outcomes, metastasis potential, immunotherapies resistance [26, 27],
DOWN: better prognosis