Fig. 1

Graphical analysis of the common path values across the three cancers. a: Upset plot representing the number of coincident significant paths between cancers. For each cancer type, two groups have been created: the group of the up-activated paths (denoted by UP), and the group of the down-activated paths (denoted by DOWN). Therefore, the same path can not be at the same time in the same cancer’s UP and DOWN groups. Red and blue horizontal bars represent the number of significant paths in each group. Each vertical bar in the plot represents the intersection of the groups in the inferior rows with a solid point, and the exclusion of the groups in the inferior rows with a shaded point. An orange box surrounds the part of the UpSet plot representing the paths which are significant in all three cancers. The blue and red vertical bars represent the paths which are simultaneously down- and up-regulated in the three cancers, respectively. b: Heatmaps of the significantly common path values, represented inside the orange box of the UpSet plot above. Samples and paths were ordered following the results of a hierarchical clusterization. Tumor samples are colored in blue while normal tissue samples are colored in light blue. In the heatmap, higher activation path values are colored in red and lower activation path values in blue. Left: BRCA cancer data. Center: KIRC cancer data. Right: LUAD cancer data