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Table 3 Modelling the 3D structures of TMTCs

From: Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites

  TMTC1 TMTC2 TMTC3 TMTC4
Sequence identity with template
(5EZM/5F15)
9.4% 10.6% 9.5% 11.3%
Modelled regions 23–456 1–336 & 393–474 4–428 17–464
Loop between TM6-TM7 240–257 207–220 209–231 242–262
Loop between TM9-TM10 393–406 411–419 *365–373 401–409
DUF1736 region
(JM3)
284–358 (321–335) 247–321 (284–298) 258–331 (294–308) 292–366 (329–343)
  1. The table provides the sequence identities of template 5EZM/5F15 with TMTCs, the range of the modelled regions, the longer loops between TM6-TM7 and TM8-TM9 compared with the templates, and location of DUF1736 along with JM3 (*residues 365–369 continue to be helical with TM9). TMTC2 has another unusual, longer cytoplasmic loop between TM8-TM9 (residues 337–392) which is not modelled in the absence of any template