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Table 2 HHPred search with N-terminal part of four human TMTCs against Pfam-A_v33.1

From: Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites

Pfam domain TMTC1
(1–456)
TMTC2
(1–475)
TMTC3
(1–426)
TMTC4
(1–462)
Glyco_transf_22 (PF03901, 388 AA) 2.1E-20 1E-18 1.5E-20 6.4E-19
Q: 29–456 Q: 3–475 Q: 9–426 Q: 22–462
T: 1–352 T: 1–351 T: 2–350 T: 1–350
STT3
(PF02516, 458 AA)
5.5E-19 2.1E-17 1.8E-19 9.5E-18
Q: 26–456 Q: 1–473 Q: 5–423 Q: 19–459
T: 3–406 T: 4–400 T: 3–401 T: 3–401
PTPS_related (PF10131, 616 AA) 1.4E-15 9.7E-14 2.5E-16 4.3E-15
Q: 89–456 Q: 62–475 Q: 67–425 Q: 81–462
T: 1–308 T: 1–308 T: 1–307 T:1–308
PMT
(PF02366, 247 AA)
2.3E-14 1.3E-13 1.5E-14 2.1E-13
Q: 30–285 Q: 3–248 Q: 9–259 Q: 23–293
T: 2–242 T: 1–242 T: 2–242 T: 2–242
Mannosyl_trans2 (PIG-V) (PF04188, 432 AA) 6E-14 1.9E-12 3.8E-14 1.4E-12
Q: 51–451 Q: 25–470 Q: 30–426 Q: 44–462
T: 60–425 T: 60–425 T: 60–429 T: 60–427
Dpy19
(PF10034, 651 AA)
8.4E-13 1.8E-12 4.4.E-13 3E-12
Q: 46–455 20–474 27–424 39–460
30–502 30–503 (651) 32–499 (651) 30–499 (651)
AftA_N
(PF12250, 432 AA)
3.6E-12 3.7E-11 3.1E-13 1.6E-11
T: 27–446 T: 3–465 T: 7–399 T: 20–435
Q: 76–430 Q: 78–431 Q: 76–402 Q: 75–402
PMT_2
(PF13231, 159 AA)
3.7E-13 1.1E-11 6.3E-13 1.6E-12
Q: 91–276 Q: 64–234 Q: 69–250 Q: 83–284
T: 1–156 T: 1–156 T: 1–156 T: 1–159
Arabinose_trans (PF04602, 471 AA) 6.3E-11 5.9E-09 1.1E-10 1.6E-10
Q: 34–456 Q: 8–468 Q: 13–426 Q: 27–462
T: 51–428 T: 51–423 T: 51–430 T: 51–427
PIG-U
(PF06728, 363 AA)
9.8E-11 7.8E-09 2.1E-10 5E-09
Q: 47–456 Q: 6–475 Q: 14–423 Q: 45–462
T: 30–349 T: 1–350 T: 1–345 T: 35–349
Mannosyl_trans4 (PF15971, 163 AA) 9.4E-11 1E-09 6.2E-11 3.9E-10
Q: 81–276 Q: 59–234 Q: 59–250 Q: 78–285
T: 1–162 T: 6–161 T: 1–162 T: 6–162
Glucos_trans_II (PF14264, 312 AA) 6.4E-07 2.8E-06 7.6E-08 5.6E-07
Q: 45–413 Q: 19–431 Q: 24–385 Q: 38–421
T: 5–310 T: 5–310 T: 5–310 T: 5–310
GT87
(PF09594, 251 AA)
3.5E-07 6.4E-06 1.1E-06 1.5E-06
Q: 91–389 Q: 64–406 Q: 68–360 Q: 82–396
T: 2–251 T: 2–249 T: 1–248 T: 1–248
  1. The functionally annotated hits with best E-values are listed: PF03901, Alg9-like mannosyltransferase family; PF02516, Oligosaccharyl transferase STT3 subunit; PF10131, 6-pyruvoyl-tetrahydropterin synthase related domain, function unknown; PF02366, Dolichyl-phosphate-mannose-protein mannosyltransferase; PF04188, Mannosyltransferase (PIG-V); PF10034, Q-cell neuroblast polarisation, function unknown; PF12250, Arabinofuranosyltransferase N terminal domain; PF13231, Dolichyl-phosphate-mannose-protein mannosyltransferase; PF04602, Mycobacterial cell wall arabinan synthesis protein; PF06728, GPI transamidase subunit PIG-U; PF15971, Dolichyl-phosphate-mannose mannosyltransferase; PF14264, Glucosyl transferase Gtr II; PF09594, Glycosyltransferase family 87. For each query and each Pfam entry (listed as Pfam entry name and ID), we provide the E-value and the sequence ranges hit in the query (Q) and in the template (T; we also provide the length of the template in parentheses below the Pfam model name)