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Table 1 HHPred search with the N-terminal part of the four human TMTCs against PDB (PDB_mmCIF70_29_May, version 29/05/2020)

From: Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites

PDB ID N-TMTC1
(1–456) 		N-TMTC2
(1–475) 		N-TMTC3
(1–426) 		N-TMTC4
(1–462)
5ezmA/5f15A
(578 AA)
[58] 		1.9E-22 5.9E-19 1.3E-21 4.2E-21
Q: 1–456 Q: 1–475 Q: 2–424 Q: 1–460
T: 7–399 T: 33–400 T: 27–395 T: 12–395
6s7tA
(826 AA)
[59] 		1.8E-17 2.3E-15 3.1E-17 1.2E-16
Q: 1–456 Q: 2–475 Q: 2–425 Q: 1–462
T: 48–560 T: 75–559 T: 70–558 T: 53–559
6s7oA
(705 AA)
[65] 		2.2E-17 4.9E-15 3.4E-17 4.1E-17
Q: 8–456 Q: 2–475 Q: 1–426 Q: 1–461
T: 1–479 T: 21–480 T: 12–477 T: 1–476
6eznF
(718 AA)
[74] 		1.4E-17 3E-15 5.1E-17 1.7E-16
Q: 9–454 Q: 1–474 Q: 2–424 Q: 3–461
T: 1–467 T: 19–469 T: 14–465 T: 1–466
3wajA
(875 AA)
[75] 		2.6E-17 8.6E-15 1.8E-17 1E-15
Q: 12–456 Q: 1–474 Q: 1–425 Q: 7–459
T: 1–490 T: 16–490 T: 9–489 T: 1–486
5oglA
(713 AA)
[60] 		2E-16 5.7E-14 4.5E-16 1.1E-15
Q: 11–455 Q: 2–475 Q: 1–426 Q: 4–462
T: 1–432 T: 18–343 T: 12–433 T: 1–434
6p25A/6p2rA
(817 AA)
[59] 		5.7E-14 7.8E-13 6.3E-14 1.8E-13
Q: 1–453 Q: 2–473 Q: 1–257 Q: 1–303
T: 26–703 T: 53–705 T: 45–290 T: 32–304
7bvfA
(1102 AA)
[76] 		1.9e-12 1.2e-10 1.1e-12 2.2e-11
Q: 33–456 Q: 7–473 Q: 13–426 Q: 26–462
T: 263–631 T: 263–631 T: 263–633 T: 263–630
6sniX/6snhX
(562 AA)
[77] 		1.5E-10 1.3E-08 1.8E-11 1.2E-09
Q: 1–416 Q: 1–434 Q: 1–388 Q: 1–424
T: 30–411 T: 54–411 T: 49–411 T: 35–411
  1. The eight essentially full-length hits with best E-values and sequence coverage > 90% are tabulated: 5ezm, crystal structure of ArnT from Cupriavidus metallidurans in the apo state [58], 5f15 is the same as 5ezm but with undecaprenyl phosphate as analogue for a lipid-linked sugar substrate; 6s7t, cryo-EM structure of human oligosaccharyltransferase complex OST-B [59]; 6s7o, cryo-EM structure of human oligosaccharyltransferase complex OST-A [65]; 6ezn, cryo-EM structure of the yeast oligosaccharyltransferase (OST) complex [74]; 3waj, crystal structure of the Archaeoglobus fulgidus oligosaccharyltransferase (O29867_ARCFU) complex with Zn and sulfate [75]; 5ogl, structure of bacterial oligosaccharyltransferase PglB in complex with an acceptor peptide and an lipid-linked oligosaccharide analogue [60]; 6p25/6p2r, structure of Saccharomyces cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor and a peptide acceptor/without peptide ligand [59]; 7bvf_A, Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [76]. We added also 6sni/6snh (cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab or with Dol25-P-Glc [77]) because of the much shorter template length. For each query and each PDB structure (listed as PDB ID), we provide the E-value and the sequence ranges hit in the query (Q) and in the template (T; we also provide the length of the template in parentheses below the PDB identifier). The uppercase letter behind the PDB identifier denotes the relevant chain
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