Skip to main content
Fig. 4 | Biology Direct

Fig. 4

From: Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

Fig. 4

DILI-related processes inferred from predicted targets and pathway annotations. Processes were based on SVM (red) and RF (yellow) models or both (orange) on the DILI (−vLessConcern) dataset. All processes are linked to the corresponding over-represented proteins in grey (19 proteins with highest feature importance). Multiple highly similar genesets were combined to arachidonic acid metabolism, Cytochrome P450 and biotransformation with the individual genesets being mapped in Table S3. Biotransformation and Cytochrome P450 are identified by both methods, while additional pathways identified by SVM point to lipid metabolism and cell cycle, and TP53 regulation is identified by RF. Moreover, arachidonic acid metabolism (SVM) and prostaglandin synthesis (RF), two biologically closely related processes, are identified

Back to article page