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Table 1 Connectivity of metabolic genes under positive selection compared to the rest of metabolic genes of the global metabolic network

From: Gene connectivity and enzyme evolution in the human metabolic network

Test Connectivity Ng Nr Mean Sampling mean p-value
M7/M8 Degree 67 707 0.0016 0.0063 < 0.0001
Test 2 Degree 9 99 0.0061 0.0063 0.8382
CEU Complete Degree 13 27 0.0010 0.0055 0.0044
CHB Complete Degree 22 238 0.0017 0.0055 < 0.0001
CEU Incomplete Degree 19 100 0.0097 0.0055 < 0.0001
CHB Incomplete Degree 15 143 0.0076 0.0055 0.0015
M7/M8 In-degree 67 707 0.0008 0.0035 < 0.0001
Test 2 In-degree 9 99 0.0044 0.0035 0.1312
CEU Complete In-degree 13 27 0.0005 0.0029 0.0210
CHB Complete In-degree 22 238 0.0007 0.0029 < 0.0001
CEU Incomplete In-degree 19 100 0.0008 0.0030 0.0004
CHB Incomplete In-degree 15 143 0.0011 0.0029 0.0004
M7/M8 Out-degree 67 707 0.0007 0.0028 < 0.0001
Test 2 Out-degree 9 99 0.0018 0.0028 0.022
CEU Complete Out-degree 13 27 0.0004 0.0026 0.0174
CHB Complete Out-degree 22 238 0.0010 0.0026 < 0.0001
CEU Incomplete Out-degree 19 100 0.0090 0.0026 < 0.0001
CHB Incomplete Out-degree 15 143 0.0065 0.0026 < 0.0001
  1. Ng: number of genes in the global metabolic network under positive selection in the mammalian lineage (M7/M8), the human lineage (Test 2) or in recent human evolution (Incomplete and Complete selective sweeps in Europeans (CEU) and Asian (CHB) populations); Nr: number of enzymatic reactions coded by the genes under positive selection; Mean: mean connectivity value of the genes under positive selection; Sampling mean: mean connectivity value of the sampling distribution based on all metabolic genes; p-value: two-sided exact p-value calculated using 10,000 Monte Carlo simulations. P-values < 0.05 are highlighted in bold.