Gene connectivity and enzyme evolution in the human metabolic network

Biology Direct

Table 1 Connectivity of metabolic genes under positive selection compared to the rest of metabolic genes of the global metabolic network

Test	Connectivity	Ng	Nr	Mean	Sampling mean	p-value
M7/M8	Degree	67	707	0.0016	0.0063	< 0.0001
Test 2	Degree	9	99	0.0061	0.0063	0.8382
CEU Complete	Degree	13	27	0.0010	0.0055	0.0044
CHB Complete	Degree	22	238	0.0017	0.0055	< 0.0001
CEU Incomplete	Degree	19	100	0.0097	0.0055	< 0.0001
CHB Incomplete	Degree	15	143	0.0076	0.0055	0.0015
M7/M8	In-degree	67	707	0.0008	0.0035	< 0.0001
Test 2	In-degree	9	99	0.0044	0.0035	0.1312
CEU Complete	In-degree	13	27	0.0005	0.0029	0.0210
CHB Complete	In-degree	22	238	0.0007	0.0029	< 0.0001
CEU Incomplete	In-degree	19	100	0.0008	0.0030	0.0004
CHB Incomplete	In-degree	15	143	0.0011	0.0029	0.0004
M7/M8	Out-degree	67	707	0.0007	0.0028	< 0.0001
Test 2	Out-degree	9	99	0.0018	0.0028	0.022
CEU Complete	Out-degree	13	27	0.0004	0.0026	0.0174
CHB Complete	Out-degree	22	238	0.0010	0.0026	< 0.0001
CEU Incomplete	Out-degree	19	100	0.0090	0.0026	< 0.0001
CHB Incomplete	Out-degree	15	143	0.0065	0.0026	< 0.0001

Ng: number of genes in the global metabolic network under positive selection in the mammalian lineage (M7/M8), the human lineage (Test 2) or in recent human evolution (Incomplete and Complete selective sweeps in Europeans (CEU) and Asian (CHB) populations); Nr: number of enzymatic reactions coded by the genes under positive selection; Mean: mean connectivity value of the genes under positive selection; Sampling mean: mean connectivity value of the sampling distribution based on all metabolic genes; p-value: two-sided exact p-value calculated using 10,000 Monte Carlo simulations. P-values < 0.05 are highlighted in bold.

ISSN: 1745-6150