Fig. 2

Relationship between recent selection in humans and metabolic functions. Individual metabolic pathways were classified based on a global view of the metabolism as a three-layered system as described in [5]. Mean ± standard error of the residuals of a linear regression of the Hierarchical Boosting (HB) scores controlling for genomic variables (CDS length, codon bias, and GC content) is plotted for each category. a) Complete HB scores in CEU, b) Incomplete HB scores in CEU, c) Complete HB scores in CHB, and d) Incomplete HB scores in CHB. Inner Core: Glycolysis / Tricarboxylic Acid Cycle / Pentose Phosphate and Polysaccharides; Intermediate: Membrane Lipids, Nucleotide, Fatty Acid / Triacylglyceride, Cofactor, Fatty Acid / Hormone, and Amino acid; Outer: Steroid, Secondary Metabolism and Detoxification. Pair-wise p-values are adjusted by FDR (ns: p > 0.05; *: p < = 0.05; **: p < = 0.01; ***: p < = 0.001; ****: p < = 0.0001)