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Fig. 3 | Biology Direct

Fig. 3

From: Interface residues of transient protein-protein complexes have extensive intra-protein interactions apart from inter-protein interactions

Fig. 3

same as in Fig. 2, but for (a) Staphostatin (inhibitor) -staphopain (cysteine proteinase) complex (PDB code: 1pxv) and (c) prostaphopain B structure which is the precursor form of staphopain proteinase (PDB code 1x9y). Cysteine proteinase is shown in green colour and the inhibitor in pink. (b) and (d) show the interactions in the zoomed up form corresponding to an interface residue, Met 289. The side chain of Met 289 is shown in red, those of intra-protein interacting residues in green and those of inter-protein interacting residues in pink, as in Fig. 2. Most of the intra-protein interactions of one interface residue, Met 289 involved in bifurcated interactions, is shown to be retained as in the uncomplexed precursor form. Interestingly, one of the key intra-protein interactions (Met 289 to Leu 338), observed in the precursor form is replaced by two inter-protein interactions (Met 289 of protease to Ile 97 of the inhibitor)

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