Biology Direct

Table 8 Synergies between data sets

From: Integration of multiple types of genetic markers for neuroblastoma may contribute to improved prediction of the overall survival

Data set	MA-145
	OOB				Cross-validation
Feature set	MA⁵⁰	CNV	MA+CNV	Syn.	MA⁵⁰	CNV	MA+CNV	Syn.
Stage 2
T-test	0.693	0.537	0.693	-0.001	0.709	0.546	0.698	-0.011
IG-1D	0.729	0.617	0.755	0.026	0.737	0.632	0.765	0.028
IG-2D	0.721	0.484	0.740	0.019	0.731	0.493	0.750	0.020
T-test + lasso	0.808	0.536	0.804	-0.004	0.831	0.553	0.827	-0.004
Stage 3
T-test	0.714	0.479	0.717	0.004	0.647	0.192	0.632	-0.015
IG-1D	0.747	0.583	0.764	0.017	0.661	0.258	0.662	0.001
IG-2D	0.730	0.514	0.740	0.010	0.655	0.308	0.656	0.000
T-test+lasso	0.808	0.506	0.825	0.017	0.648	0.194	0.652	0.005
	G-145
	OOB				cross-validation
Feature set	G⁵⁰	CNV	G+CNV	Syn.	G⁵⁰	CNV	G+CNV	Syn.
Stage 2
T-test	0.714	0.537	0.720	0.006	0.716	0.546	0.725	0.009
IG-1D	0.766	0.617	0.780	0.014	0.778	0.632	0.786	0.009
IG-2D	0.743	0.484	0.747	0.004	0.756	0.493	0.757	0.001
T-test+lasso	0.848	0.536	0.853	0.005	0.865	0.553	0.868	0.003
Stage 3
T-test	0.714	0.478	0.730	0.016	0.650	0.192	0.640	-0.011
IG-1D	0.747	0.582	0.786	0.039	0.661	0.258	0.662	0.001
IG-2D	0.730	0.511	0.767	0.037	0.650	0.308	0.650	0.000
T-test+lasso	0.808	0.506	0.858	0.050	0.655	0.194	0.655	0.000

Synergies between data sets displayed for two stages of the analysis for MA+CNV and G+CNV data sets. MA⁵⁰ and G⁵⁰ are sets MA-145 and G-145 data sets limited to top 50 variables, respectively. Cases, for which MCC for mixed model is higher then either of the components, suggesting possible synergy are highlighted in boldface

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