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Table 2 Circuits that deactivate DNA repair and related cell functions

From: Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome

Circuit (Pathway and effector protein)

Status

FDR p-value

GO ID

GO Definition

Jak-STAT signaling pathway: MYC

DOWN

1.94E-32

GO:2001022

positive regulation of response to DNA damage stimulus

MAPK signaling pathway: MYC

DOWN

1.39E-26

GO:2001022

positive regulation of response to DNA damage stimulus

ErbB signaling pathway: MYC

DOWN

7.15E-24

GO:2001022

positive regulation of response to DNA damage stimulus

Wnt signaling pathway: MYC

DOWN

7.78E-22

GO:2001022

positive regulation of response to DNA damage stimulus

Hippo signaling pathway: MYC

DOWN

7.12E-13

GO:2001022

positive regulation of response to DNA damage stimulus

Jak-STAT signaling pathway: MYC

DOWN

1.94E-32

GO:0006338

chromatin remodeling

MAPK signaling pathway: MYC

DOWN

1.39E-26

GO:0006338

chromatin remodeling

ErbB signaling pathway: MYC

DOWN

7.15E-24

GO:0006338

chromatin remodeling

Wnt signaling pathway: MYC

DOWN

7.78E-22

GO:0006338

chromatin remodeling

Hippo signaling pathway: MYC

DOWN

7.12E-13

GO:0006338

chromatin remodeling