Accumulation of potential driver genes with genomic alterations predicts survival of high-risk neuroblastoma patients

Table 1 Cox proportional-hazard regression models of survival

Model	Variable	Hazard ratio	P ^*
Model 1a	DGscore	2.69	0.008
Model 1b	Tumor stage	1.41	0.52
Model 1c	MYCN amplification	1.18	0.65
Model 1d	Age	1.00	0.058
Model 2	DGscore+tumor stage^a
	DGscore	2.69	0.008
	Tumor stage	1.41	0.52
Model 3	DGscore+MYCN^b
	DGscore	2.68	0.007
	MYCN amplification	1.15	0.70
Model 4	DGscore+age
	DGscore	2.67	0.008
	Age	1.00	0.064
Model 5	Age + MYCN + tumor stage
	Age	1.00	0.021
	MYCN amplification	1.98	0.12
	Tumor stage	1.89	0.28
Model 6	DGscore+Age + MYCN + tumor stage
	DGscore	2.69	0.008
	Age	1.00	0.02
	MYCN amplification	2.02	0.12
	Tumor stage	1.94	0.27

^aStage 4/4S are compared against Stage I-III; ^bNo MYCN amplification is used as reference group; ^*P-values from the Wald test

ISSN: 1745-6150