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Table 2 Protein partners of CLN3 matching to the aforementioned search criteria

From: Molecular mechanisms of the juvenile form of Batten disease: important role of MAPK signaling pathways (ERK1/ERK2, JNK and p38) in pathogenesis of the malady

Protein partner of CLN3 Function Interaction with receptor complexes Putative signal cascade activation Level of protein expression in the brain
KCNIP3 [28] Voltage-gated potassium (Kv) channel-interacting protein IGF1R [12] MAPKs High
TFRC [6] A cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis EGFR [13], NTRK1 [14] MAPKs High