Skip to main content

Table 2 Protein partners of CLN3 matching to the aforementioned search criteria

From: Molecular mechanisms of the juvenile form of Batten disease: important role of MAPK signaling pathways (ERK1/ERK2, JNK and p38) in pathogenesis of the malady

Protein partner of CLN3

Function

Interaction with receptor complexes

Putative signal cascade activation

Level of protein expression in the brain

KCNIP3 [28]

Voltage-gated potassium (Kv) channel-interacting protein

IGF1R [12]

MAPKs

High

TFRC [6]

A cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis

EGFR [13], NTRK1 [14]

MAPKs

High