TY - JOUR AU - Kumar, Gayatri AU - Mudgal, Richa AU - Srinivasan, Narayanaswamy AU - Sandhya, Sankaran PY - 2018 DA - 2018/05/09 TI - Use of designed sequences in protein structure recognition JO - Biology Direct SP - 8 VL - 13 IS - 1 AB - Knowledge of the protein structure is a pre-requisite for improved understanding of molecular function. The gap in the sequence-structure space has increased in the post-genomic era. Grouping related protein sequences into families can aid in narrowing the gap. In the Pfam database, structure description is provided for part or full-length proteins of 7726 families. For the remaining 52% of the families, information on 3-D structure is not yet available. We use the computationally designed sequences that are intermediately related to two protein domain families, which are already known to share the same fold. These strategically designed sequences enable detection of distant relationships and here, we have employed them for the purpose of structure recognition of protein families of yet unknown structure. SN - 1745-6150 UR - https://doi.org/10.1186/s13062-018-0209-6 DO - 10.1186/s13062-018-0209-6 ID - Kumar2018 ER -