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Table 1 Zero-frame observed/expected (obs/exp) synonymous substitution ratios and corresponding p-values for the TF region

From: ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?

Gene

Taxon

Synonymous site conservation

obs/exp

p-value

ASXL1

mammals

0.33

3.3 × 10−82

 

sauropsids

0.55

4.4 × 10−29

 

amphibians

0.43

6.3 × 10−19

 

tetrapods

0.43

4.8 × 10−121

 

teleosts

0.52

3.2 × 10−49

ASXL2

mammals

0.68

7.6 × 10−22

 

sauropsids

0.86

5.7 × 10−3

 

amphibians

0.75

6.0 × 10−4

 

tetrapods

0.74

1.3 × 10−22

  1. Note that these p-values are for the entire TF ORF and therefore can be lower than the 25-codon sliding window p-values of Fig. 3 and Additional file 1: Fig. S2