TY - JOUR AU - Catalán, Pablo AU - Arias, Clemente F. AU - Cuesta, Jose A. AU - Manrubia, Susanna PY - 2017 DA - 2017/02/28 TI - Adaptive multiscapes: an up-to-date metaphor to visualize molecular adaptation JO - Biology Direct SP - 7 VL - 12 IS - 1 AB - Wright’s metaphor of the fitness landscape has shaped and conditioned our view of the adaptation of populations for almost a century. Since its inception, and including criticism raised by Wright himself, the concept has been surrounded by controversy. Among others, the debate stems from the intrinsic difficulty to capture important features of the space of genotypes, such as its high dimensionality or the existence of abundant ridges, in a visually appealing two-dimensional picture. Two additional currently widespread observations come to further constrain the applicability of the original metaphor: the very skewed distribution of phenotype sizes (which may actively prevent, due to entropic effects, the achievement of fitness maxima), and functional promiscuity (i.e. the existence of secondary functions which entail partial adaptation to environments never encountered before by the population). SN - 1745-6150 UR - https://doi.org/10.1186/s13062-017-0178-1 DO - 10.1186/s13062-017-0178-1 ID - Catalán2017 ER -