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Table 3 At most sites of selection identified using ExpCM, mutations affect drug resistance or immune escape

From: Identification of positive selection in genes is greatly improved by using experimentally informed site-specific models

Gene Site Affects biologically relevant phenotype?
β-lactamase 35 No evidence implicating this site in resistance [15]
  48 No evidence implicating this site in resistance [15]
  104 E104K involved in β-lactam resistance [15]
  112 No evidence implicating this site in resistance [15]
  164 R164C, R164H, and R164S involved in β-lactam resistance [15]
  182 M182T potentiates resistance [15]
  238 G238S involved in β-lactam resistance [15]
  240 E240K involved in β-lactam resistance [15]
  244 R244C, R244H, and R244S involved in inhibitor resistance [15]
NP 20 In a T-cell epitope [94]
  101 In an antibody epitope [95]
  105 In a T-cell epitope [96]
  131 Not part of known immune epitope
  290 In an antibody epitope [97]
  319 Not part of known immune epitope
  371 In an antibody epitope [98, 99]
  375 E375G interacts with T-cell escape mutation at 384 [58, 100]
  384 R384G and R384K are T-cell escape mutations [38, 100]
  422 K422R is a T-cell escape mutation [101]
HA 138 Contacts antigenic-site residues defined by the experiments of [40]
  189 Contacts antigenic-site residues defined by the experiments of [40]
  225 An antigenic site residue defined by the experiments of [40]; also affects receptor-binding specificity and so known to undergo substitutions both during host adaptation and viral passaging in the lab [8487]