Table 2 Molecular biomarkers that were identified by at least 2 of the approaches with frequency of 100% in any of the three cross-validation rounds
From: Prognostic value of cross-omics screening for kidney clear cell renal cancer survival
Molecular type | Molecular biomarker | Extreme score stratific. | Mean score stratific. | Extreme survival stratific. | Survival prognosis association |
|---|---|---|---|---|---|
miRNA | hsa-mir-10b | ✓ | ✓ | ✓ | High expression in better outcome |
hsa-mir-130a; hsa-mir-21 | ✓ | ✓ | ✓ | High expression in worse outcome | |
hsa-mir-190; hsa-mir-204; hsa- mir-676 | ✓ | ✓ | High expression in better outcome | ||
hsa-let-7i | ✓ | ✓ | High expression in worse outcome | ||
hsa-mir-130b; hsa-mir-18a; hsa- mir-365-1; hsa-mir-223; hsa- mir-92b | ✓ | ✓ | High expression in worse outcome | ||
hsa-mir-3613 | ✓ | ✓ | High expression in worse outcome | ||
hsa-mir-374b; hsa-mir-590 | ✓ | ✓ | High expression in worse outcome | ||
mRNA | ADH5; ARHGAP24; CLDN10; EHHADH; EIF4EBP2; FBXL5; GIPC2; IMPA2; MFSD4; SALL1; SORBS2; TPRG1L; LRBA; RBM47; RETSAT; RGNEF; SH3BGRL2 | ✓ | ✓ | ✓ | High expression in better outcome |
AMOT; BBS1; CDC14B; EPHX2; FARS2; KCNJ15; PINK1; RAB3IP; STK32B; ZNF704; | ✓ | ✓ | High expression in better outcome | ||
ACADM; ALDH6A1; AMD1; ANK3; ATP11A; C5orf23; CCDC121; CLCN5; CPT2; CRYL1; CYFIP2; DDAH1; DMRTA1; FCHO2l; MAP7; MIA2; MOBKL2B; MRPS18B; NPR3; PANK1; PRKAA2; PRUNE2; SLC16A12; SLC27A2; SPATA18; TFEC; TMEM192; TMEM27; TMEM38B; TOX3; WDR31; | ✓ | ✓ | High expression in better outcome | ||
ACOX1; ALDH3A2; HLF; TIMP3; TMEM150C; UFSP2; | ✓ | ✓ | High expression in better outcome | ||
Protein | AR; CTNNA1; CTNNB1; GAB2 | ✓ | ✓ | ✓ | High expression in better outcome |
ACACA; CDKN1A; EA15; RAD51 | ✓ | ✓ | ✓ | High expression in worse outcome | |
ERRFI1; IGF1R; MAPK1 MAPK3; SHC1 | ✓ | ✓ | High expression in better outcome | ||
EEF2 | ✓ | ✓ | High expression in worse outcome | ||
TSC2 | ✓ | ✓ | High expression in better outcome | ||
IGFBP2; VASP | ✓ | ✓ | High expression in worse outcome | ||
DNA methylation probes | cg03032025 (CPEB4) | ✓ | ✓ | High methylation in worse outcome | |
cg14827391 (NXN) cg15743907 (PDE4DIP) cg16419354 (FAM163A) cg24332577 (SALL4) | ✓ | ✓ | High methylation in worse outcome |