TY - JOUR AU - Sorokina, Irina AU - Mushegian, Arcady PY - 2016 DA - 2016/12/01 TI - The role of the backbone torsion in protein folding JO - Biology Direct SP - 64 VL - 11 IS - 1 AB - The set of forces and sequence of events that govern the transition from an unfolded polypeptide chain to a functional protein with correct spatial structure remain incompletely known, despite the importance of the problem and decades of theory development, computer simulations, and laboratory experiments. Information about the correctly folded state of most proteins is likely to be present in their sequences, and yet many proteins fail to attain native structure after overexpression in a non-native environment or upon experimental denaturation and refolding. SN - 1745-6150 UR - https://doi.org/10.1186/s13062-016-0166-x DO - 10.1186/s13062-016-0166-x ID - Sorokina2016 ER -