TY - JOUR AU - Korwek, Zbigniew AU - Tudelska, Karolina AU - Nałęcz-Jawecki, Paweł AU - Czerkies, Maciej AU - Prus, Wiktor AU - Markiewicz, Joanna AU - Kochańczyk, Marek AU - Lipniacki, Tomasz PY - 2016 DA - 2016/11/11 TI - Importins promote high-frequency NF-κB oscillations increasing information channel capacity JO - Biology Direct SP - 61 VL - 11 IS - 1 AB - Importins and exportins influence gene expression by enabling nucleocytoplasmic shuttling of transcription factors. A key transcription factor of innate immunity, NF-κB, is sequestered in the cytoplasm by its inhibitor, IκBα, which masks nuclear localization sequence of NF-κB. In response to TNFα or LPS, IκBα is degraded, which allows importins to bind NF-κB and shepherd it across nuclear pores. NF-κB nuclear activity is terminated when newly synthesized IκBα enters the nucleus, binds NF-κB and exportin which directs the complex to the cytoplasm. Although importins/exportins are known to regulate spatiotemporal kinetics of NF-κB and other transcription factors governing innate immunity, the mechanistic details of these interactions have not been elucidated and mathematically modelled. SN - 1745-6150 UR - https://doi.org/10.1186/s13062-016-0164-z DO - 10.1186/s13062-016-0164-z ID - Korwek2016 ER -