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Fig. 6 | Biology Direct

Fig. 6

From: Emergence of heterogeneity in acute leukemias

Fig. 6

Impact of cooperativity between mutations on depth of the hierarchy. The figure is based on 100 simulated patients. The number of patients harboring a clonal hierarchy of depth 4 or more is maximized, if the jumps in the trait spaces increase with the number of mutations. Parameters: Self-renewal and proliferation rates of the leukemic founder clone are drawn from normal distributions with mean values equal to proliferation and self-renewal rates of healthy cells and standard deviation σ 1=0.0014. First mutation: self-renewal and proliferation rates of the new clone are normally distributed with the means of the distributions equal to proliferation and self-renewal rates of the founder clone and standard deviation σ 2=5·σ 1. Second mutation: self-renewal and proliferation rates of the new clone are normally distributed with the means of the distributions equal to proliferation and self-renewal rates of the parent clone and standard deviation σ 3=20·σ 1. Third and higher mutations: self-renewal and proliferation rates of the new clone are normally distributed with the means of the distributions equal to proliferation and self-renewal rates of the parent clone and standard deviation σ 3=100·σ 1. Mutation rate ν=5·10−9

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