Fig. 3
Self-renewal rate of significant clones increases during the course of the disease. The figure is based on 600 simulated patients. a Time evolution of one simulated patient who developed 4 clones during the course of the disease. The first, second, third and fourth significant clone are depicted using different colors. b Self-renewal rates of the first, second, third and fourth significant leukemic clone of the subgroup of patients harboring 4 significant clones at the end of the simulation (reduction of healthy cell count by 95 %). The self-renewal rates differ significantly (p<0.05 in t-test) between first and second, second and third, third and fourth clone. c Self-renewal rates of the first, second and third significant leukemic clone of the subgroup of patients harboring 3 clones at the end of simulations. The self-renewal rates differ significantly between the clones (p<0.05 in t-test). d Proliferation rates of the first, second and third significant leukemic clone of the subgroup of patients harboring 3 clones at the end of simulation. The proliferation rates do not differ significantly between the clones (p>0.05 in t-test). Parameters: mutation rate ν=5·10−9, self-renewal and proliferation rates of the new clones are normally distributed with the means of the distributions equal to proliferation and self-renewal rates of the parent clone and standard deviation equal to 0.005. The central mark is the median, the edges of the box are the 25th and 75th percentiles, points are drawn as outliers if they are larger than q 3+1.5(q 3−q 1) or smaller than q 1−1.5(q 3−q 1), where q 1 and q 3 are the 25th and 75th percentiles, respectively