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Fig. 6 | Biology Direct

Fig. 6

From: Long range personalized cancer treatment strategies incorporating evolutionary dynamics

Fig. 6

A minimal population dynamic model for a 2 drug system with four phenotypic states. S = sensitive cells. R1 = cells resistant to drug 1 and sensitive to drug 2. R2 = cells resistant to drug 2 and sensitive to drug 1. R1-2 = cells resistant to both drugs. Arrows indicate reversible genetic or epigenetic transitions between phenotypic states. Each phenotypic state may represent a cluster of related genotypes. Reproduced from [40] with permission

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