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Table 5 Selected pathways and genes on NSCLC RNA-seq data (stage segmentation)

From: Weighted-SAMGSR: combining significance analysis of microarray-gene set reduction algorithm with pathway topology-based weights to select relevant genes

 

Pathways with high frequency (frequency %)

Genes (frequency %)

SAMGSR

DNA_FRAGMENTATION_DURING_APOPTOSIS (70 %)

SODIUM_CHANNEL_ACTIVITY (70 %)

TGFB2 (80 %) SHROOM2 (80 %) CECR2 (70 %) SCN4B (70 %) CFTR (70 %)

Stability = 18.28 %

Stability = 24.48 %

Weighted-SAMGSR

ANION_CHANNEL_ACTIVITY (100 %)

CHLORIDE_CHANNEL_ACTIVITY (100 %) ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY (90 %)

AXON (90 %) APICAL_PART_OF_CELL (90 %)

NEURON_PROJECTION (90 %) ANION_TRANSPORT (80 %) REGULATION_OF_MAPKKK_CASCADE (80 %) GROWTH_CONE (80 %)

REGULATION_OF_HEART_CONTRACTION (80 %) REGULATION_OF_MUSCLE_CONTRACTION (80 %)

SITE_OF_POLARIZED_GROWTH (70 %) PROTEIN_FOLDING (70 %)

CFTR (100 %) TGFB2 (80 %) MAPT (80 %) MAPK8IP3 (70 %) TPM1 (70 %)

Stability = 42.75 %

Stability = 32.38 %

  1. Note: Gene symbols in bold are those overlapped genes by SAMGSR and weighted-SAMGSR; gene symbols underlined are directly related to NSCLC according to the genecards database
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Biology Direct

ISSN: 1745-6150

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