Skip to main content

Advertisement

Table 5 Selected pathways and genes on NSCLC RNA-seq data (stage segmentation)

From: Weighted-SAMGSR: combining significance analysis of microarray-gene set reduction algorithm with pathway topology-based weights to select relevant genes

  Pathways with high frequency (frequency %) Genes (frequency %)
SAMGSR DNA_FRAGMENTATION_DURING_APOPTOSIS (70 %)
SODIUM_CHANNEL_ACTIVITY (70 %)
TGFB2 (80 %) SHROOM2 (80 %) CECR2 (70 %) SCN4B (70 %) CFTR (70 %)
Stability = 18.28 % Stability = 24.48 %
Weighted-SAMGSR ANION_CHANNEL_ACTIVITY (100 %)
CHLORIDE_CHANNEL_ACTIVITY (100 %) ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY (90 %)
AXON (90 %) APICAL_PART_OF_CELL (90 %)
NEURON_PROJECTION (90 %) ANION_TRANSPORT (80 %) REGULATION_OF_MAPKKK_CASCADE (80 %) GROWTH_CONE (80 %)
REGULATION_OF_HEART_CONTRACTION (80 %) REGULATION_OF_MUSCLE_CONTRACTION (80 %)
SITE_OF_POLARIZED_GROWTH (70 %) PROTEIN_FOLDING (70 %)
CFTR (100 %) TGFB2 (80 %) MAPT (80 %) MAPK8IP3 (70 %) TPM1 (70 %)
Stability = 42.75 % Stability = 32.38 %
  1. Note: Gene symbols in bold are those overlapped genes by SAMGSR and weighted-SAMGSR; gene symbols underlined are directly related to NSCLC according to the genecards database