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Table 1 ROC-AUC and PR-AUC values for 43 Human PDZ domains with real negative interaction data

From: modPDZpep: a web resource for structure based analysis of human PDZ-mediated interaction networks

Domain

ROC-AUC

PR-AUC

#Binder

#Non-binder

DLG4_1

0.53

0.52

71

5

DLG4_3

0.74

0.76

89

5

ErbinLAP2

0.79

0.84

43

13

GIPC1_TIP_2

0.64

0.60

26

13

GOPC

0.32

0.34

13

8

GRIP2_2

0.47

0.69

6

5

GRIP2_3

0.78

0.82

8

5

InaDl_1

0.66

0.74

48

7

InaDl_2

0.80

0.86

53

7

InaDl_3

0.71

0.74

67

7

InaDl_4

0.68

0.75

40

7

InaDl_5

0.67

0.64

43

7

InaDl_6

0.60

0.58

41

6

InaDl_7

0.56

0.54

36

7

InaDl_8

0.45

0.52

30

6

InaDl_9

0.43

0.52

31

7

LIN7B

0.14

0.31

11

6

MAGI1_3

0.86

0.86

53

27

MAGI1_5

0.75

0.70

14

30

MAGI2_1

0.84

0.86

22

10

MAGI2_4

0.68

0.78

21

15

MAGI2_5

0.68

0.73

20

16

MAGI2_6

0.77

0.79

21

9

MAGI3_1

0.68

0.64

11

12

MAGI3_2

0.78

0.82

11

9

MAGI3_3

0.77

0.82

19

11

MAGI3_4

0.90

0.93

30

12

MUPP1_10

0.69

0.68

39

5

MUPP1_11

0.78

0.83

18

8

MUPP1_12

0.81

0.81

25

8

MUPP1_13

0.86

0.86

42

6

MUPP1_1

0.97

0.98

79

5

MUPP1_2

0.93

0.94

53

5

MUPP1_3

0.94

0.95

53

5

MUPP1_4

0.93

0.95

19

5

MUPP1_5

0.94

0.96

37

5

MUPP1_6

0.8

0.88

12

5

MUPP1_7

0.94

0.96

32

5

MUPP1_8

0.85

0.85

18

6

MUPP1_9

0.93

0.95

37

6

PICK1

0.51

0.56

36

6

PTPN13_PTPL1_PTP1E_1

0.53

0.62

15

5

PTPN13_PTPL1_PTP1E_2

0.63

0.64

35

8

Average

0.71

0.75

-

-

  1. In cases where number of non-binders was much less compared to the number of binders, AUC was calculated by dividing the binders into multiple sets such that, approximately equal number of binder and non-binder were in each set and average AUC values are reported