Fig. 3

Histograms showing quality of structural models obtained for human PDZ domains. a Number of models is plotted against the sequence identity between the target and template PDZ sequences. 118 out of 169 PDZ domains have >40 % sequence identity to the PDZ domain structures used as template for generating the structural models, while crystal structures were available for 91 human PDZ domains. b Number of models is plotted against the RMSD of PDZ Structural models to the peptide bound templates calculated with TM-align. Most of the PDZ domains show <2.5 Ȧ RMSD to the peptide bound templates