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Fig. 4 | Biology Direct

Fig. 4

From: Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations

Fig. 4

The cytotoxic drug triggers a population bottleneck. Sample dynamics of the population density n(x,t) (panel a) and the total number of cells ρ(t) (panel b) in the case when the drug concentration c(·)=C corresponds to the LC70 dose. The values of the model parameters are as in Table 1, and the initial condition corresponds to a population composed of different cellular clones [cf. Eq. (8)]. The inset of panel (b) displays the population density after 40 days [i.e., n(x,40)], which coincides with the equilibrium population density \(\overline {n}_{c}(x)\) of Eq. (16)

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