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Fig. 1 | Biology Direct

Fig. 1

From: Should tissue structure suppress or amplify selection to minimize cancer risk?

Fig. 1

The difference between the fixation probability on a small graph and the fixation probability in a well-mixed population. Top: For a suppressor of selection, in this case the directed line, deleterious mutations have a higher fixation probability, whereas advantageous mutations have a lower fixation probability. The shaded region shows the fitness values for which mutations on this graph have a higher probability of taking over the population than in the well-mixed population. Bottom: For an amplifier of selection, here a random undirected graph, the fixation probability of advantageous mutations (shaded region) is increased, but the fixation probability of slightly deleterious mutations is decreased

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