The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans

Biology Direct

Table 4 Tissue-specifically expressed subsets of genes in relevant human tissues^a

Protein sets tested and expression sets used (columns) Tissue types (rows)	NQ-rich proteins^b		Prion predictions by PLAAC^b		Prion predictions by PAPA^b		DISORDERED PROTEINS (>70 % set)^b
	GXA Illumina body map expression library	Specond	GXA Illumina body map expression library	Specond	GXA Illumina body map expression library	Specond	GXA Illumina body map expression library	Specond
Brain	38/1966 (1.9 %, N.S.)	9/503 (1.8 %, N.S.)	10/1966 (0.5 %, N.S.)	3/503 (0.6 %, N.S.)	25/1966 (1.3 %, N.S.)	8/503 (1.6 %, N.S.)	127/1966 (6.5 %, N.S.)	42/503 (8.4 %, N.S.)
Spinal Cord	N/A	3/262 (1.1 %, N.S.)	N/A	2/262 (1.1 %, N.S.)	N/A	3/262 (1.1 %, N.S.)	N/A	31/262 (11.8 %, P = 0.001)
Skeletal Muscle	25/ 753 (3.3 %, P = 0.015)	5/270 (1.9 %, N.S.)	6/753 (0.8 %, N.S.)	3/270 (1.1 %, N.S.)	4/753 (0.5 %, N.S.)	4/270 (1.5 %, N.S.)	52/752 (7.0 %, N.S.)	19/270 (7.0 %, N.S.)

^aEnrichments are in bold type. For each is listed the fraction, with the percentage and hypergeometric P-value in brackets (N.S. = not significant)
^bFor NQ-rich proteins, the LPS threshold used is 1e-10 (overall fraction is 414/22699, 1.8 %). The PLAAC and PAPA predictions use default values (overall fractions: 136 / 22699 (0.6 %) PLAAC; 279 / 22699 (1.2 %) PAPA). In all cases, human protein composition is used for these annotations. The disordered proteins are annotated as described in Methods

ISSN: 1745-6150