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Table 4 Tissue-specifically expressed subsets of genes in relevant human tissuesa

From: The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans

Protein sets tested and expression sets used (columns) Tissue types (rows) NQ-rich proteinsb Prion predictions by PLAACb Prion predictions by PAPAb DISORDERED PROTEINS (>70 % set)b
GXA Illumina body map expression library Specond GXA Illumina body map expression library Specond GXA Illumina body map expression library Specond GXA Illumina body map expression library Specond
Brain 38/1966 (1.9 %, N.S.) 9/503 (1.8 %, N.S.) 10/1966 (0.5 %, N.S.) 3/503 (0.6 %, N.S.) 25/1966 (1.3 %, N.S.) 8/503 (1.6 %, N.S.) 127/1966 (6.5 %, N.S.) 42/503 (8.4 %, N.S.)
Spinal Cord N/A 3/262 (1.1 %, N.S.) N/A 2/262 (1.1 %, N.S.) N/A 3/262 (1.1 %, N.S.) N/A 31/262 (11.8 %, P=0.001)
Skeletal Muscle 25/ 753 (3.3 %, P=0.015) 5/270 (1.9 %, N.S.) 6/753 (0.8 %, N.S.) 3/270 (1.1 %, N.S.) 4/753 (0.5 %, N.S.) 4/270 (1.5 %, N.S.) 52/752 (7.0 %, N.S.) 19/270 (7.0 %, N.S.)
  1. aEnrichments are in bold type. For each is listed the fraction, with the percentage and hypergeometric P-value in brackets (N.S. = not significant)
  2. bFor NQ-rich proteins, the LPS threshold used is 1e-10 (overall fraction is 414/22699, 1.8 %). The PLAAC and PAPA predictions use default values (overall fractions: 136 / 22699 (0.6 %) PLAAC; 279 / 22699 (1.2 %) PAPA). In all cases, human protein composition is used for these annotations. The disordered proteins are annotated as described in Methods