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Table 1 The overall proportion of generations that each reaction spent as rate limiting is shown, pooled across each replication, for each experiment

From: Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable

  Reaction 1 Reaction 2 Reaction 3 Reaction 4 Reaction 5
Positive control 0.9998 0.0002 0.0000 0.0000 0.0000
Selection on flux only 0.1201 0.2048 0.1499 0.3314 0.1937
Selection on flux and against protein expression cost 0.2137 0.2732 0.1961 0.1790 0.1380
Selection on flux and against a deleterious intermediate 0.7018 0.0259 0.0421 0.0814 0.1488