Fig. 4From: Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stableClustering of co-evolving parameters across simulations. Colors represent parameters which are found to cluster together (at the 5Â % level), while black parameters were not found to have significant associations with clusters. Panels show results from simulations with a mutation only, b selection on flux only, c selection on flux and against total expression cost, d selection on flux and against a high concentration of a deleterious intermediate, and e non-biological neutral mutation and selection on flux and for the first reaction to be rate limitingBack to article page