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Fig. 4 | Biology Direct

Fig. 4

From: Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable

Fig. 4

Clustering of co-evolving parameters across simulations. Colors represent parameters which are found to cluster together (at the 5 % level), while black parameters were not found to have significant associations with clusters. Panels show results from simulations with a mutation only, b selection on flux only, c selection on flux and against total expression cost, d selection on flux and against a high concentration of a deleterious intermediate, and e non-biological neutral mutation and selection on flux and for the first reaction to be rate limiting

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