Fig. 1

IUPred profile of four representative HKMTs and CBP. Regions with corresponding PDB structures (red¹), SCOP domains (green), conserved predicted binding regions (yellow), known binding regions (orange horizontal lines) and cancer associated SNPs (black diamonds) are indicated. ¹List of PDB structures: MLL1: 4gq6_b, 3u88_m, 2mtn_a, 2msr_a, 2j2s_a, 2kyu_a, 3lqh_a, 2agh_c, 2w5y_a; MLL4: 3uvk_b, 3erq_d, 4z4p_a; NSD1: 3ooi_a; DOT1L: 3uvp_a, 2mv7_b; CBP: 1rdt_e, 1lik_a, 2lxt_a, 4n4f_a, 2kje_a