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Fig. 7 | Biology Direct

Fig. 7

From: Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Fig. 7

Normal stress response. Numerical solution for the response to a 120 min external stress I ext=0.1. a At the moment the external stress is turned on, the value of (q,c) increases from its initial stable solution at (64.4,27) to (71,27) after which the circulating CRH level c, quickly reaches the fast c-nullcline (black) before slowly evolving along it towards the slow q-nullcline (blue). After short durations of stress, the system returns to its starting point within the normal state basin. b The peaks of the cortisol level are increased during stress (red) but return to their original oscillating values after the stress is turned off

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