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Fig. 10 | Biology Direct

Fig. 10

From: Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Fig. 10

Stress-induced transitions to high-cortisol oscillating state. a Projected 2D system dynamics when a stressor of amplitude I ext=0.2 is applied for 9 min starting at T=120 min. c is increased just above the unstable branch (c≈20) to allow the unstressed system to cross the separatrix and transition to the normal high-c stable state. b The plot of o(T) shows the transition to the high-cortisol, high-oscillation amplitude state shortly after the 9 min stress. c A stressor turned off after 780 min (13 hrs) leaves the system in the basin of attraction of the diseased state. d Cortisol levels are pushed up but after about 1400 min relax back to levels of the original diseased state

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