Table 7 Normalized root-mean-square error calculated for each experimental dataset utilized in the context of model fitting

KPL-4 (Bevacizumab monotherapy study)

[60]

Control

500.25

10.76

2.15 %

Treatment

83.23

7.00

8.41 %

(5 mg/kg)

KPL-4 (Bevacizumab combination treatment study)

[60]

Control

639.84

13.31

2.08 %

Treatment

165.70

11.77

7.10 %

(5 mg/kg)

H226

[61]

Control

603.07

16.73

2.77 %

Treatment 1

241.23

22.22

9.21 %

(1 mg/kg)

Treatment 2

177.17

8.09

4.57 %

(5 mg/kg)

Treatment 3

76.32

21.17

27.74 %

(25 mg/kg)

HSCC1

[61]

Control

504.05

10.27

2.04 %

Treatment 1

188.87

27.80

14.72 %

(1 mg/kg)

Treatment 2

164.08

27.87

16.99 %

(5 mg/kg)

Treatment 3

125.12

9.71

7.76 %

(25 mg/kg)

HCT116

[62]

Control

2902.71

121.76

4.19 %

Treatment

1411.98

74.85

5.30 %

(15 mg/kg)

HCP40

[62]

Control

2992.56

47.88

1.60 %

Treatment

178.66

9.31

5.21 %

(15 mg/kg)

HT29

[62]

Control

2381.34

58.17

2.44 %

Treatment

1276.84

129.88

10.17 %

(15 mg/kg)

HP40

[62]

Control

2484.60

100.50

4.04 %

Treatment

1454.25

93.24

6.41 %

(15 mg/kg)