Numerical simulation of vascular tumour growth under antiangiogenic treatment: addressing the paradigm of single-agent bevacizumab therapy with the use of experimental data

Table 2 Effect of the variation of one input parameter value at a time, on the value of the tumour plateau as well as on the timepoint of its attainment

Parameter values			Units	Time of plateau (day)	Value of plateau (mm³)	Variation of plateau value (%)
λ ₁	Reference value	0.192	day⁻¹	95	17347	n/a
	+20 %	0.2304		79	17347	0
	−20 %	0.1536		118	17347	0
c	Reference value	5.85	day⁻¹	95	17347	n/a
	+20 %	7.02		96	22803	+31.45 %
	−20 %	4.68		101	12413	−28.44 %
d	Reference value	0.00873	day⁻¹ · mm⁻²	95	17347	n/a
	+20 %	0.010476		87	13196	−23.93 %
	−20 %	0.006984		99	24243	+39.75 %

All results regarding variation of plateau value are in agreement with the respective calculations based on Eq. (9)

ISSN: 1745-6150